PUBLICATIONs

Since 1996, Dr. Kurosu and his team have published extensively in medicinal chemistry, microbiology, and infectious disease, contributing peer-reviewed articles, book chapters, and patents. Their work has advanced antibacterial drug discovery, with a focus on natural products, host-directed therapies, and treatments for drug-resistant infections.

PATENTS

HIGHLIGHTED

PEER-REVIEWED

BOOKS

PATENTS

Glycosyltransferase inhibitors for treatment of solid tumors.

Kurosu, M.; Clemons, Clemons, W. M. International Patent Application No. PCT/US2019/013152, filed January 12, 2019.
Pleuromutilin derivatives and uses thereof:

U.S Provisional Application February, 2017. Kurosu, M.
Compounds for amide-forming reactions

Patent number: WO 2013180815, Issue date: March 15, 2013. Kurosu, M
Composition for the Treatment of Tuberculosis and Methods of Using Same

WO 2013-US24290, Issue date: Feb 1, 2013. Kurosu, M
Improved Synthesis of Capuramycin and its Analogues.

U.S Provisional Application No.: 61/869,390 Filed September, 2013. Kurosu, M.
(2,2-Dimethyl-1,3-dioxolane-4yl)methyl 2-cyano-2-(hydroxyimino)acetate and Method of Use

Filed May 10, 2012. Kurosu, M.
Compositions and Methods of Use of Electron Transport System Inhibitors.

Serial Number: PCT / US, 2007 / 63122. Kurosu, M.
Acid and Base Stable Diphenylmethanol Derivatives and Methods of Use.

U.S. Pat. Appl. Publ. 2008, US 2008200719 A1 20080821. Kurosu, M.

Natural Product Chemistry (Highlighted)

Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis.

Mitachi, K.; Aleiwi, B. A.; Schneider, C. M.; Siricilla, S.; Kurosu, M. J. Am. Chem. Soc. 2016, 138, 12975-12980.
Improved Synthesis of Capuramycin and Its Analogs.

Wnag, Y.; Siricilla, S.; Aleiwi, B. A.; Kurosu, M. Eur. Chem. A Europ. J. 2013, 19, 13847-13858.
A New Oxyma Derivative for Non-racemizable Amide-forming Reactions in Water.

Wang, Q.; Wang, Y.; Kurosu, M. Org. Lett. 2012, 14, 3372-3375.
Selective Esterifications of Primary Alcohols in a Water-Containing Solvent.

Wang, Y.; Aleiwi, B. A.; Wang, Q.; Kurosu, M. Org. Lett. 2012, 14, 4910-4913.
A Concise Synthesis of Capuramycin.

Kurosu, M.; Li, K.; Crick, D. C. Org. Lett. 2009,11, 2393-2396.
Ganglioside GM3 Derivatives with Truncated Ceramide Moiety: Facial Synthesis and Inhibitory Activity Against KB Cell Growth.

Kurosu, M.; Kitagawa, I. J. Carbohydrate.Chem. 2006, 25, 427.
Fe/Cr-and Co/Cr Mediated catalytic Asymmetric 2-Haloallylations of Aldehydes.

Kurosu, M.; Lin, M-H.; Kishi, Y, J. Am.Chem. Soc. 2004, 126, 12248-12249.
Total Synthesis of (±)-Batrachotoxinin A.

Kurosu, M.; Marcin, L. R.; Grinsteiner, T. J.; Kishi. Y. J. Am. Chem. Soc. 1998, 120, 6627-6628.
A Novel Example for Optical Resolution of Racemic Ketones Originating from Batrachotoxin Synthesis.

Kurosu, M.; Kishi, Y. J. Org. Chem. 1998, 63, 6100-6101.

Peer-Reviewed Publications

Development of Novel DPAGT1 Inhibitors based on Tunicamycin V and its Homologous Structures.

Mitachi, K.; Kurosu, M. Journal of Synthetic Organic Chemistry, Japan. 2023, 81, 220-234.
DOI: doi.org/10.5059/yukigoseikyokaishi.81.220
Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor.

Mitachi, K.; Mingle, D.; Effah, W.; Sánchez-Ruiz, A.; Hevener, K.E.; Narayanan, R.; Clemons, W.M.; Sarabia, F.; Kurosu, M. Angew. Chem. Int. Ed. 2022.
DOI: doi.org/10.1002/anie.202203225
DPAGT1 Inhibitors of capuramycin analogues and their antimigratory activities of solid tumors.

Mitachi, K.; Kansal, R.; Hevener, K.; Gillman, C.; Yun, H-G.; Hussain, M.; Miranda-Carboni, G.; Glazer, E.; Clemons, W. M.; Kurosu, M. J. Med. Chem. 2020, 63, 10855-10878.
DOI: doi.org/10.1021/acs.jmedchem.0c00545
Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-based Assays.

Mitachi, K.; Yun, H-G.; Gillman, C.; Skorupinska-Tudek, K.; Swiezewska, E.; Clemons, W. M.; Kurosu, M. ACS Inf. Dis. 2020, 6, 1501-1516.
DOI: doi.org/10.1021/acsinfecdis.9b00242
Application of Mycobacterium smegmatis as a surrogate to evaluate drug leads against Mycobacterium tuberculosis.

Lelovic, N.; Mitachi, K.; Yang, J.; Lemieux, M. R.; Ji, Y.; Kurosu, M. J. Antibiotics 2020, 73, 780-789.
DOI: doi.org/10.1038/s41429-020-0320-7
A practical synthesis of a novel DPAGT1 inhibitor, aminouridyl phenoxypiperidinbenzyl butanamide (APPB) for in vivo studies.

Mitachi, M.; Kurosu, S. M.; Gillman, C. D.; Yun, H-G.; Clemons, W. M.; Kurosu, M. MethodsX 2019, 6, 2305-2321.
DOI: doi.org/10.1016/j.mex.2019.09.031
Structure-based drug discovery N-glycan biosynthesis, dolichyl-phosphate N-acetylglucosaminephosphotransferase.

Kurosu, M. Future Med. Chem. 2019, 11, 927-933.
DOI: doi.org/10.4155/fmc-2018-0405
Semisynthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate.

Mitachi, K.; Kurosu, M. S.; Eslamimehr, S.; Lemieux, M. R.; Ishizaki, Y.; Clemons C. M. Jr., Kurosu, M. Org. Lett. 2019,214, 876-879.
DOI: doi.org10.1021/acs.orglett.8b03716
Novel FR-900493 Analogs that Inhibit Germination of Clostridium difficile Spores.

Mitachi, K.; Yun, H-G.; Kurosu, S. M.; Eslamimehr, S.; Lemieux, M. R.; Klaić, L.; Clemons C. M. Jr., Kurosu, M.ACS Omega. 2018
A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of MDR Acinetobacter baumannii.

Siricilla,S.; Mitachi,K.; Yang, J.; Eslamimehr, S.; Lemieux, M. R.; Meibohm, B.; Ji, Y.; Kurosu, M. J. Med. Chem. 2017, 60, 2869-2878.
Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis.

Mitachi, K.; Aleiwi, B. A.; Schneider, C. M.; Siricilla, S.; Kurosu, M. J. Am. Chem. Soc. 2016, 138, 12975-12980.
Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.

Mitachi, K.; Siricilla, S.; Yang, D.; Kong, Y.; Skorupinska-Tudek, K.; Swiezewska, E.; Franzblau, S. G.; Kurosu, M. Analytical Biochemistry 2016, 512, 78-90.
Structure determination of lipopeptides from Mycobacterium avium subspecies paratuberculosis and identification of antigenic lipopeptide probes.

Mitachia, K.; Sharma Gautama L.H.; Rice, J. H.; Eda K.; Wadhwa A.; Momotani, E.; Hlopak, J. H.; Eda, S.; Kurosu, M. Analytical Biochemistry 2016, 505, 29-35.
Discovery of a Capuramycin analog that Kills Non-replicating Mycobacterium tuberculosis and Its Synergistic Effects with Translocase I Inhibitors.

Siricilla, S.; Mitachi, K.; Wan, B.; Franzblau, S. G.; Kurosu, M. J. Antibiot. 2014, 68, 271-278.
One-Pot Protection-Glycosylation Reactions for Synthesis of Lipid II Analogues.

Katsuhiko, M.; Priya, M.; Shajila, S.; Kurosu, M. Chem. A Europ. J. 2014, 20, 4554-4558.
Biosynthesis of A Water-Soluble Lipid I Analogue and A Convenient Assay for Translocase I

Siricilla, S.; Mitachi, K.; Skorupinska-Tudek, K.; Swiezewska, E.; Kurosu, M. Analytical Biochem. 2014, 46, 36-45.
Improved Synthesis of Capuramycin and Its Analogs.

Wnag, Y.; Siricilla, S.; Aleiwi, B. A.; Kurosu, M. Eur. Chem. A Europ. J. 2013, 19, 13847-13858.
Advances in MRSA drug discovery: where are we and where do we need to be?

Kurosu, M.; Mitachi, K.; Siricilla, S. Expert Opni. Rev. 2013, 8, 1095-1116.
Selective Esterifications of Primary Alcohols in a Water-Containing Solvent

Wang, Y.; Aleiwi, B. A.; Wang, Q.; Kurosu, M. Org. Lett. 2012, 14, 4910-4913.
A New Oxyma Derivative for Non-racemizable Amide-forming Reactions in Water.

Wang, Q.; Wang, Y.; Kurosu, M. Org. Lett. 2012, 14, 3372-3375.
Vitamin K2 in Electron Transport System: Are Enzymes Involved in Vitamin K2 Biosynthesis Promising Drug Targets?

Kurosu, M.; Begari, E. Molecules, 2010, 15, 1531-1553.
Bacterial Protein Kinase Inhibitors.

Kurosu, M.; Begari, E. Drug Development Research 2010, 71, 168-187.
A Concise Synthesis of Capuramycin.

Kurosu, M.; Li, K.; Crick, D. C. Org. Lett. 2009,11, 2393-2396.
New Chiral Derivatizing Agents: Convenient Determination of Absolute Determination of Free Amino Acids by 1H-NMR.

Kurosu, M.; Li, K. Org. Lett. 2009, 11, 911-914.
MenA Is a Promising Drug Target for Developing Novel lead Molecules to Combat Mycobacterium tuberculosis.

Kurosu, M.; Crick, D. C. Medicinal Chemistry 2009, 5, 197-207.
Menaquinone Synthesis Is Critical for Maintaining Mycobacterial Viability During Exponential Growth and Recovery from Non-replicating Persistence.

Dhiman, R. K.; Mahapatra, S.; Slayden, R. A.; Boyne, M. E.; Lenaerts, A.; Hinshaw, J. C.; Angala, S. K.; Chatterjee, D.; Biswas, K.; Narayanasamy, P.; Kurosu, M.; Crick, D. C. Molecular Microbiology 2009, 72, 85-97.
Discovery of 1,4-Dihydroxy-2-naphthoate Prenyltransferase Inhibitors: New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens.

Kurosu, M.; Narayanasamy, P.; Biswas, K.; Dhiman, R.; Crick, D. C. J. Med. Chem. 2007, 50, 3973-3975.
Polymer-Supported (2,6-Dichloro-4-alkoxyphenyl) (2,4-dichlorophenyl) methanol: A New Linker for Solid-Phase Organic Synthesis.

Kurosu, M.; Biswas, K.; Crick, D. C. Org. Lett. 2007, 9, 1141-1144.

BOOK PUBLICATIONS

Medicinal Chemistry of Chemotherapeutic Agents

Editors Archarya, P.; Kurosu, M. ELSEVIER UK (2023)

Available Here
Advances in Tuberculosis Medicinal Chemistry

Editors Kurosu, M. Future Science Ltd, Unitec House, UK

Read Here
Vitamin K2 Biosynthesis: Drug Targets for New Antibacterials

Chapter 15. Published: 22 March 2017

Available Here
Biologically Active Molecules from Soybeans in Soybean and Health (2011)

1-24, INTECH, ISBN 978-953-307-535-8

Read Here
Cell Wall Biosynthesis and Latency during Tuberculosis Infections (2019)

Kurosu, M. in Tuberculosis Host-Pathogen Interactions

Read Here
Electrophile cleavable linker unit In Linker Strategies in Solid-Phase Organic Synthesis (2009)

27-76 John Wiley and Sons, Ltd.

Read Here

PUBLICATIONs

Glycosyltransferase inhibitors for treatment of solid tumors.

Pleuromutilin derivatives and uses thereof:

Compounds for amide-forming reactions

Composition for the Treatment of Tuberculosis and Methods of Using Same

Improved Synthesis of Capuramycin and its Analogues.

(2,2-Dimethyl-1,3-dioxolane-4yl)methyl 2-cyano-2-(hydroxyimino)acetate and Method of Use

Compositions and Methods of Use of Electron Transport System Inhibitors.

​ Acid and Base Stable Diphenylmethanol Derivatives and Methods of Use.

Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis.

Improved Synthesis of Capuramycin and Its Analogs.

A New Oxyma Derivative for Non-racemizable Amide-forming Reactions in Water.

Selective Esterifications of Primary Alcohols in a Water-Containing Solvent.

A Concise Synthesis of Capuramycin.

Ganglioside GM3 Derivatives with Truncated Ceramide Moiety: Facial Synthesis and Inhibitory Activity Against KB Cell Growth.

Fe/Cr-and Co/Cr Mediated catalytic Asymmetric 2-Haloallylations of Aldehydes.

Total Synthesis of (±)-Batrachotoxinin A.

A Novel Example for Optical Resolution of Racemic Ketones Originating from Batrachotoxin Synthesis.

Development of Novel DPAGT1 Inhibitors based on Tunicamycin V and its Homologous Structures.

Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor.

DPAGT1 Inhibitors of capuramycin analogues and their antimigratory activities of solid tumors.

Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-based Assays.

Application of Mycobacterium smegmatis as a surrogate to evaluate drug leads against Mycobacterium tuberculosis.

A practical synthesis of a novel DPAGT1 inhibitor, aminouridyl phenoxypiperidinbenzyl butanamide (APPB) for in vivo studies.

Structure-based drug discovery N-glycan biosynthesis, dolichyl-phosphate N-acetylglucosaminephosphotransferase.

Semisynthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate.

Novel FR-900493 Analogs that Inhibit Germination of Clostridium difficile Spores.

A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of MDR Acinetobacter baumannii.

Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis.

Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.

Structure determination of lipopeptides from Mycobacterium avium subspecies paratuberculosis and identification of antigenic lipopeptide probes.

Discovery of a Capuramycin analog that Kills Non-replicating Mycobacterium tuberculosis and Its Synergistic Effects with Translocase I Inhibitors.

One-Pot Protection-Glycosylation Reactions for Synthesis of Lipid II Analogues.

Biosynthesis of A Water-Soluble Lipid I Analogue and A Convenient Assay for Translocase I

Improved Synthesis of Capuramycin and Its Analogs.

Advances in MRSA drug discovery: where are we and where do we need to be?

​ Selective Esterifications of Primary Alcohols in a Water-Containing Solvent

A New Oxyma Derivative for Non-racemizable Amide-forming Reactions in Water.

Vitamin K2 in Electron Transport System: Are Enzymes Involved in Vitamin K2 Biosynthesis Promising Drug Targets?

Bacterial Protein Kinase Inhibitors.

A Concise Synthesis of Capuramycin.

New Chiral Derivatizing Agents: Convenient Determination of Absolute Determination of Free Amino Acids by 1H-NMR.

MenA Is a Promising Drug Target for Developing Novel lead Molecules to Combat Mycobacterium tuberculosis.

Menaquinone Synthesis Is Critical for Maintaining Mycobacterial Viability During Exponential Growth and Recovery from Non-replicating Persistence.

Discovery of 1,4-Dihydroxy-2-naphthoate Prenyltransferase Inhibitors: New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens.

Polymer-Supported (2,6-Dichloro-4-alkoxyphenyl) (2,4-dichlorophenyl) methanol: A New Linker for Solid-Phase Organic Synthesis.

Medicinal Chemistry of Chemotherapeutic Agents

Advances in Tuberculosis Medicinal Chemistry

Vitamin K2 Biosynthesis: Drug Targets for New Antibacterials

Biologically Active Molecules from Soybeans in Soybean and Health (2011)

Cell Wall Biosynthesis and Latency during Tuberculosis Infections (2019)

Electrophile cleavable linker unit In Linker Strategies in Solid-Phase Organic Synthesis (2009)

MK Consulting

Acid and Base Stable Diphenylmethanol Derivatives and Methods of Use.

Selective Esterifications of Primary Alcohols in a Water-Containing Solvent